When Is Mlb Opening Day 2025 Sf Giants. 18—the cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati. Logan webb, robbie ray, jordan hicks, kyle harrison, hayden birdsong.

San francisco will open the season against the cincinnati reds on march 27 at great american ball park and will wrap up the 2025 campaign against the colorado rockies on september 28 at oracle park. San francisco giants opening day 2025!